Rybelsus works by enhancing insulin secretion in a glucose-dependent manner, slowing gastric emptying, and reducing appetitemechanisms that generally improve blood glucose control rather than worsen it
BY INTRAMUSCULAR INJECTION Adult: Initially 1 mg 3 times a week for 2 weeks, then 1 mg every 2-3 months
On average, clinical trials have found that patients on semaglutide (the active ingredient in Ozempic and Wegovy) may lose between 15% to 20% of their body weight within the first year of use
Downsides include potential gastrointestinal side effects, nausea, diarrhea, gas, and constipation
Gjermeni E, Kirstein AS, Kolbig F, Kirchhof M, Bundalian L, Katzmann JL, Laufs U, Blher M, Garten A, Le Duc D (2021) ObesityAn update on the Basic Pathophysiology and Review of recent therapeutic advances