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Abbreviations PCOS: Polycystic ovary syndrome POI: Premature ovarian insufficiency GPX4: Glutathione peroxidase 4 GSH: Glutathione LPCAT3: Lysophosphatidylcholine acyltransferase 3 NCOA4: Nuclear receptor coactivator 4 ACSL4: Acyl-CoA synthetase long-chain family member 4 TfR1: Transferrin receptor 1 FPN: Ferroportin PUFAs: Polyunsaturated fatty acids ROS: Reactive oxygen species ALOX15: Arachidonate 15-lipoxygenase LOX: Lipoxygenase LIP: Labile iron pool IREB2: Iron-responsive element-binding protein 2 Tf: Transferrin FTH1: Ferritin heavy chain 1 FSH: Follicle-stimulating hormone LH: Luteinizing hormone NCOA4: Nuclear receptor coactivator 4 FSP1: Ferroptosis suppressor protein 1 ACSL4: Acyl-CoA synthetase long-chain family member 4 SCD1: Stearoyl-CoA desaturase 1 CD44: Cluster of differentiation 44 HO-1: Heme oxygenase-1 NRF2: Nuclear factor erythroid 2-related factor 2 References Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascn S, Hatzios SK, Kagan VE et al (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease

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and the National Natural Science Foundation of China (Grant No