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In type 2 diabetes management, for example, NICE guideline NG28 supports the use of multiple agents with complementary mechanisms when monotherapy is insufficient
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Their action significantly reduced 4-HNE levels in renal tissue, with Fe and MDA levels decreasing by 38% and 42%, respectively, significantly alleviating damage to renal tubular epithelial cells and improving renal function indicators such as serum creatinine and blood urea nitrogen [63]
Macromolecules 30:74787486
These therapies have been shown to prevent the onset of macroalbuminuria and slow the progression of glomerular filtration rate (GFR) decline in diabetic patients [25]
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