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In 2-year rat carcinogenicity studies referenced in the Increlex label, increased mammary and skin tumor incidence occurred at high IGF-1 exposure

Liquid formulations also tend to have shorter shelf lives once opened, as the peptide in solution is more susceptible to degradation than in solid form

The absence of manufacturing oversight increases exposure to compounds of unverified quality

It is placed under the tongue or between the cheek and gum, where it dissolves slowly over 15 to 30 minutes, allowing the peptide to absorb through the oral mucosa into the bloodstream

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