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Regarding metabolic parameters, Cagrilintide treatment did not produce significant changes in HbA1c or fasting plasma glucose from baseline to week 26, while liraglutide 3.0 mg significantly improved both measures, consistent with its known glucose-lowering effects

In contrast, TIGAR overexpression or treatment with Fer-1, a ferroptosis inhibitor, significantly increases NADPH, GPX4, and GSH levels, reduces GSSG expression, and attenuates neuronal ferroptosis and neurological impairment

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