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In rats given BPC-157, serotonin levels in the brain increase in specific regions while simultaneously decreasing in other regions, such as the hippocampus.[ref] A 2020 study found that BPC-157 reduced leaky gut syndrome by stabilizing gut permeability after NSAID use.[ref] Reducing leaky gut theoretically can affect the gut-brain axis and reduce inflammation
Thus, the cocaine-and amphetamine-regulated transcript (CART) has been reported to have an anorexic effect after intracerebroventricular administration [141], while CART injected directly into the paraventricular or arcuate nucleus of fasted rats increases food intake [142]
Tirzepatide is a 39-amino acid synthetic peptide with agonist activity at both the GIP and GLP-1 receptors
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