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Titration: There is generally no need for upward titration with B-complex vitamins as one might do with certain drugs, but if a patient is frail or known to react to injections, the provider may choose to start at a lower dose (for example 0.25-0.5 mL) and then increase to 1 mL as tolerated

HHcy generally correlated with cumulative LDopa dose without significant association with vitamin levels (Mancini et al

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methylcobalamin Vitamin B 12 appears to have only two functions in eukaryotes: as a cofactor for the enzymes: Methionine synthase MethylmalonylCoA mutase Sources of vitamin B12 Vitamin B 12 is in the gastrointestinal tract of animals and is then absorbed by the host animal