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Updated systematic reviews further support the idea that GLP-1 RA administration does not inherently increase DR risk through specific class effects of incretin hormones but rather reflects a common phenomenon of rapid hypoglycemia correction from severe hyperglycemia (143, 147149)

Possibly some mild nausea, though sublingual formulations tend to produce less GI disturbance at initiation than injections because the daily dose is smaller and the peak concentration is lower

Lyophilized (unopened): Store at 20 C (4 F) or colder (80 C optimal) in dry, dark conditions for up to 12 months [4]

Long-term data beyond the trial periods is still being collected

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