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Additionally, Farxigas diuretic effect can cause volume depletion and low blood pressure, particularly in elderly patients or during summer months when dehydration risk is elevated

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Then-FDA Commissioner Robert Califf framed the requirement plainly: "Participants in clinical trials should be representative of the patients who will use the medical products" ( [23] )

The most common early adjustment is mild nausea during the first few weeks as your body gets used to the medication, and this typically eases significantly when the starting dose is kept low and increased gradually