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The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release
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TB-500 is the rate-limiting component due to its larger size
Additionally, BCSCs isolated from primary human breast cancers possess the advanced metastasis potential and the CD70+ subpopulations appear to preferentially mediate lung-specific metastasis by enhancing self-renewal potential (125)
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