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This is because issues with regular function of the gastrointestinal tract can prevent the proper release and absorption of the vitamin, which can cause a deficiency if not supplemented properly

A detailed look at this two-way link is in the stress and immunity article

This action was taken to prevent risks such as severe infections, which could arise from the use of non-sterile products.

Results Out of the 30 patients (18 females and 12 males) with transient lingual neurosensory disturbances, after third molar extraction, 15 used the intra-nasal vitamin B12 spray, while the other 15 took oral vitamin B12 tablets

I believe the rush toward higher doses reflects a common misconception that more equals better