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486 Worse still, the main challenge in the treatment of Alzheimers disease is that its pathogenesis has not been fully clarified, and the more recognized hypotheses of the pathogenesis include deposition of -amyloid (A) 487 and intracellular Tau protein aggregates, 488 neuroinflammation 489 and lack of acetylcholine (Ach), oxidative stress, 490 and bio-metal dyshomeostasis, etc

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