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Starting new medications that affect glucose metabolism, appetite, or gastrointestinal function may counteract tirzepatide effects

Its important to know that oral semaglutide has to be taken on an empty stomach with a small amount of water, at least 30 minutes before any food, drink, or other medications to maximize absorption, Dushay says

From 8 mg, increase to 10 or 12 mg

Historically, the liver has been acknowledged as the main location where metformin reduces glucose levels, however, there is increasing evidence suggesting that the gastrointestinal tract also plays a significant role in its action