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This concept of "biased agonism" is central to understanding why structurally similar compounds acting on the same receptor can produce different downstream effects
It can reverse cortisone-induced inhibition of wound healing and restore normal tissue repair signaling without triggering rebound inflammation
GPX1 is a tetramer that can react with H 2 O 2 and soluble low-molecular hydroperoxides, but not with more complex lipid hydroperoxides
JAMA Network Open 2025, 8: e2530346
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