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The free radical theory and the mitochondrial theory propose that elevated free radicals (oxidative stress) and mitochondrial dysfunction, respectively, are at the core of geriatric aging

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However, definitive evidence from adequately powered human trials demonstrating cognitive benefits is still lacking, and ongoing phase 3 studies are investigating these potential effects

NAD(+) metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus