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If your tirzepatide stops working after an initial period of success, this may represent a plateau rather than medication failure

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If you experience any swelling whilst taking a GLP-1 medication, consider these practical steps: Review all your medications with your pharmacist or GP, as some drugs (calcium channel blockers, NSAIDs, corticosteroids) are more likely to cause fluid retention Monitor your salt intake excessive dietary sodium can contribute to water retention Elevate your legs when sitting or lying down if you have ankle swelling Wear compression stockings if recommended by your healthcare provider (after DVT has been excluded and if appropriate for your circulation) Keep a symptom diary , noting when swelling occurs, its severity, and any associated symptoms Regular monitoring is essential for all patients on GLP-1 therapy

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