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While semaglutide demonstrated a favorable safety and tolerability profile and was associated with modest changes in AD-related biomarkers, including plasma high-sensitivity C-reactive protein and AD-relevant cerebrospinal fluid biomarkers, it did not demonstrate superiority over placebo on the primary clinical endpoint, change in the clinical dementia ratingsum of boxes (CDR-SB) score at week 104 68

In a Phase II trial, pelacarsen reduced Lp(a) levels by 3558% depending on the dose, with no significant differences in safety indicators compared with the placebo

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