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Liraglutide was associated with an average loss of 8.4 kilograms over 56 weeks in a major clinical trial

Here's the math: At steady state on a 1 mg weekly dose, your blood concentration oscillates in a predictable pattern: Peak concentration: approximately 24 to 48 hours after injection Trough concentration: immediately before your next scheduled dose (day 7) The trough is roughly 50% of the peak due to one half-life of elimination When you inject one day early (day 6 instead of day 7), you're dosing when your blood level is at approximately 57% of peak instead of 50%

Lower doses still provide meaningful effects with substantially fewer side effects

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Tsiodras, S., Mantzoros, C., Hammer, S