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Short-term GH pulses and higher IGF-1 can enhance glucose uptake in muscle and fat, reduce fasting insulin requirements, and redirect substrate utilization toward improved metabolic flexibility

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Disruption of this process, known as ER stress, is associated with many disease states, including obesity and its comorbidities (Mohan, R, Brown, Ayyappan, & G, 2019)

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61,63,64 Another function of ALP is in the formation and maintenance of canalicular microvilli on the surface of hepatocytes

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