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Discontinuation in trials: retatrutide trial discontinuation due to adverse events was 6-10% across the higher-dose arms meaningful but lower than the dose-related side-effect profile would suggest, which indicates most participants tolerated the protocol

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"FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells"

Six arms: Cagrilintide at doses 0.3, 0.6, 1.2, 2.4, 4.5 mg/week SC vs Liraglutide 3.0 mg/day vs placebo

Adherence to Standard Protocols and the Problem with One-Size-Fits-All Guidelines The Core of the Issue: The primary reason for refusal is that the GP surgery is typically following a strict protocol based on established guidelines