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KLOW's mechanism as a Klotho mimetic suggests theoretical risks including phosphate dysregulation, hypoglycemia when combined with other glucose-lowering agents, and potential immunogenicity with repeated subcutaneous dosing
Disadvantages are nausea and constipation
Wijten, P
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Moreover, GLP-1RAs have neuroprotective, anti-infectious, cardiovascular protective, and metabolic regulatory effects, exhibiting good application prospects
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