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All mice were housed under specific pathogen-free (SPF) conditions with 12 h light/12 h dark cycle at 2124 C, and humidity at 4060%, and were fed with a standard chow diet at the Laboratory Animal Center of the Sixth Affiliated Hospital, Sun Yat-sen University

J Cell Physiol 227(12):37783786 Funding This work was supported by the National Natural Science Foundation of China (Grants 61527825, 81572184, and 81471699) and the Natural Science Foundation of Guangdong Province (Grant 2014A030313378)

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