Singh suggested the discrepancy may stem from the latter studys design limitations
PARPs catalyze reversible ADP-ribosylation of macromolecules 6,49
5.7 Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists Thiazolidinediones (TZDs), which are peroxisome proliferator-activated receptor (PPAR)-gamma agonists, can cause dose-related fluid retention, when used in combination with insulin
This creates more controllable conditions for subsequent OI or ART, rather than serving as a direct means to induce ovulation or guarantee pregnancy. 8.2 Stratified clinical strategies by phenotype and reproductive intent As evidence for metabolic benefits currently outweighs that for hard ART endpoints, treatment decisions should be stratified by metabolic risk and the reproductive timeline
In fact, one recent propensity-matched analysis of non-diabetic patients found that GLP-1 use was associated with a lower incidence of UTI, 8.8% compared to 13.3% in the control group
