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The glucagon receptor activation appears to drive meaningful improvements in liver health and lipid profiles that go beyond what weight loss alone would explain
They improve metabolic health as well as obesity and reduction of systemic inflammatory states
While the inflammation-reducing and fibrosis-attenuating effects of glucagon agonism are less well-characterized, the reductions in hepatic inflammation parameters and fibrosis observed in preclinical models likely reflect secondary effects consequent to improved steatosis, rather than direct anti-inflammatory actions [21]
semaglutide 2.4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2)
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