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Key distinction: DSIP promotes sleep without sedation it supports the natural mechanisms of sleep rather than forcing unconsciousness
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LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN - amplified neuroblastoma
However, a 145-patient randomised controlled trial (RCT) reported that 4 g of paracetamol daily in divided doses for 4 days was associated with an increase in ALT activity in a significant proportion of patients when compared to placebo, although the clinical significance of this elevation in ALT is unclear [24]
