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These findings provide direct genetic evidence that variation in the drug-target genes contributes to inter-person variability in response and lay the foundation for precision medicine approaches in the treatment of obesity, they said

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These included gallbladder cancer (HR = 0.35), meningioma (HR = 0.37), pancreatic cancer (HR = 0.41), hepatocellular carcinoma (HR = 0.47), ovarian cancer (HR = 0.52), colorectal cancer (HR = 0.54), multiple myeloma (HR = 0.59), esophageal cancer (HR = 0.60), endometrial cancer (HR = 0.74), and kidney cancer (HR = 0.76)

Many patients notice changes within a few weeks, with more substantial weight loss typically observed over several months