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Kielgast U, Holst JJ, Madsbad S
Melanoma development requires a biochemical alteration in the precursor cells undergoing clonal expansion
approximately 15-30% of patients) Diarrhea (13-24%) Vomiting (6-12%) Constipation (6-17%) Abdominal pain (6-10%) Dyspepsia (6-9%) Decreased appetite (5-10%) These gastrointestinal effects are typically most pronounced during dose escalation and tend to diminish over time as the body adjusts to the medication
6A) (Han et al., 2018)
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