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Later, the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus reinforced that probiotic should be reserved for strains that are taxonomically defined, safe for their intended use, supported by at least one positive human clinical trial, and present alive at an efficacious dose throughout shelf life (18)

Massee M, Chinn K, Lei J, Lim JJ, Young CS, Koob TJ

biological activity depends on the complex and formulation (PMC)