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Option Sermorelin + Ipamorelin GHRH side Sermorelin (shorter-acting) Secretagogue side Ipamorelin Note Sermorelin is a classic GHRH but less potent/stable than tesamorelin

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And it is an increasingly important comparison, because metabolic dysfunction-associated steatotic liver disease (MASLD) affects an estimated 1.7 billion people worldwide

Both semaglutide and tirzepatide underwent randomized, placebo-controlled trials for obesity, with marked reduction of weight as shown below

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