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Substituting GIPRs C-terminal tail with that of GLP-1R significantly increased both the rate and extent of agonist-mediated endocytosis, suggesting a role for GIPRs C-terminal region in either its slower internalization or rapid recycling back to the plasma membrane
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For solution preparation, sterile handling practices including the use of sterile solvents, clean workspaces, and proper storageare necessary to preserve peptide integrity and prevent contamination
Plain language summary Hundreds of millions of people around the world live with rare diseases, but most of these conditions still dont have effective treatments
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