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2020 Jul 28;21(15):5342
These medications work by mimicking incretin hormones, enhancing insulin secretion, suppressing glucagon release, slowing gastric emptying, and reducing appetite through central nervous system pathways
For example, the ingestion of trimethylamine-containing (TMA-containing) dietary nutrients enriched in animal products such as choline, phosphatidylcholine, and l-carnitine can serve as precursor for the ultimate generation of an atherogenic metabolite, trimethylamine N -oxide (TMAO), via a metaorganismal pathway involving initial gut microbial formation of TMA, followed by host hepatic conversion of TMA into TMAO (48)
GLP-1 Side Effects While GLP-1 drug therapy is generally safe, some patients may experience mild side effects such as: Nausea Vomiting Diarrhea Constipation Headache Fatigue Most side effects lessen with time as the body adjusts