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True vitamin B12 overdose is exceptionally rare because it is water-soluble and excess amounts are excreted through urine

Topics: B12, High B12, Vitamin B12, B12 Symptoms, MCAS, Mast Cell Activation, Functional Medicine

Because of the absence of a nucleus and mitochondria, the red cell is incapable of generating energy via the (oxidative) Krebs cycle and depends mainly on the anaerobic conversion of glucose by the Embden-Meyerhof pathway (EMP, or direct glycolytic pathway) and the oxidative hexose monophosphate pathway (HMP, or pentose phosphate shunt) (Figure 23-1)

In the condition known as functional hypothyroidism, the thyroid hormones cannot control metabolism efficiently because of the excessive synthesis of rT3 and the lack of T3