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and 4 is defined as hypertonic flexor and extensor muscles [3]
Standard practice includes: Baseline thyroid function tests (TSH and free T4) before initiating GLP-1 therapy Repeat testing at 812 weeks after starting treatment or after dose escalation Regular monitoring every 36 months during active weight loss Return to annual monitoring once weight is stable and thyroid function remains consistent Adjustments to levothyroxine dosing may be necessary as weight changes
Semaglutide might indirectly improve CV and kidney-related outcomes, but the exact mechanisms by which GLP-1RAs exert beneficial effects on CV and kidney parameters are not yet elucidated, in contrast to the well-established intrarenal tubulo-glomerular feedback mechanism of SGLT2is [13]
Researchers should study its binding sites and conformational changes in depth to provide theoretical support for the design of highly selective drugs
One major concern is the skyrocketing price of GLP-1 medications
