In respect to their cardiovascular effects among patients with T2DM, both GLP-1RAs and SGLT2is have been shown to reduce the risk of MACE (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke), with GLP-1RAs reducing the risk of non-fatal stroke to a greater extent [3, 6]
they may potentially do so via the relatively permeable CVO or through endocytosis and transcytosis of vascular endothelial cells to reach the deep brain (143145)
Data are presented as the mean of three comparative cycle thresholds
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