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One telehealth provider reported their compounded semaglutide tolerates temperatures up to 95 degrees Fahrenheit for a maximum of 4 days, and up to 77 degrees for 15 days
Since the latter are thought to exert their glucose-lowering activity by preventing the degradation and inactivation (with regard to insulinotropic effects) of endogenously released intact, biologically active GLP-1 [9], their pharmacological action should critically depend on availability of the major substrate, GLP-1
10.3389/fphar.2012.00119 Front Pharmacol
However, supplementation should always be viewed as one pillar of a comprehensive, multidisciplinary management strategy
Semaglutide works by mimicking the effects of the naturally occurring hormone GLP-1, which plays a pivotal role in regulating appetite and food intake
