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In COVID-19, a cytokine storm can lead to cell death in the lungs
[57] It does this by upregulating phosphorylated IRS-1 and activating pathways (like AMPK/SIRT1) that promote the transport of the GLUT4 glucose transporter to cell membranes in muscle and adipose tissue, thereby increasing overall cellular glucose uptake
However, this changes when a drug is listed on the FDA shortage list
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