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Weight gain in Hashimoto's results from reduced basal metabolic rate due to hypothyroidism, fluid retention, fatigue, and reduced exercise tolerance
A low SAM/SAH ratio (below approximately 4:1) indicates methylation insufficiency and correlates with reduced methyltransferase activity across the board
However, due to the off-target effect as a multi-kinase inhibitor [8], therapeutic advances are directed toward targeting metabolic vulnerabilities associated with SLC7A11 pathways in cancer
The choice often comes down to personal preference and how your body responds to different delivery methods
Always consult a qualified healthcare provider before starting any new supplement, medication, or treatment
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