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Heres a quick guide Ive been working on for teaching and portfolio use: Indications & Concentrations - Anaphylaxis (IM): 1:1000 (1 mg/mL) - Cardiac Arrest (IV/IO): 1:10,000 (0.1 mg/mL) - Severe Asthma (SC/IM): 1:1000 (1 mg/mL) - Local Anesthesia adjunct: 1:100,000 1:200,000 - Microsurgery/Ophthalmic: 1:400,000 Preparation (Step-by-Step) - 1:10,000 1 mL of 1:1000 + 9 mL NS - 1:100,000 1 mL of 1:1000 + 99 mL NS - 1:200,000 0.5 mL of 1:1000 + 99.5 mL NS - 1:400,000 0.25 mL of 1:1000 + 99.75 mL NS Clinical Pearls Never give IV bolus of 1:1000 IM route is safest for anaphylaxis Always label syringes clearly Monitor ECG, BP, SpO when IV is used Avoid end-arterial infiltration with local anesthesia Takeaway: Adrenaline saves lives-but precision in dilution and administration is what makes it safe

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28 Chung et al investigated antimelanogenic effects of GSH and its derivatives in vitro