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The pharmacophore of vitamin C is the ascorbate, ascorbate is an antioxidant.Ascorbate is a neuromodulator of glutamatergic and dopaminergic system and related behaviors

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Briefly, under anesthesia induced by intraperitoneal (i.p.) injection of ketamine (80 mg/kg) and xylazine (10 mg/kg), rats were exposed to octave-band noise (816 kHz) at 108 dB SPL for 2 h