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S2 additional material).7,8 The incidence of PsO and HS has increased in western countries in recent decades.9,10 Obesity has increased in parallel, and could be responsible, at least partially, for the aforementioned increase.8 Psoriasis and obesity The prevalence of obesity is higher among patients with PsO than in the general population.1118 In addition, obesity increases the risk of PsO,6,19,20 the incidence of which could be twice as great in patients with grade II/III obesity compared with subjects with normal weight.21 Among the molecular mediators at the intersection between the 2 conditions are 3 adipokinesleptin, resistin, and adiponectinwhose levels impact the severity of PsO in patients with obesity.2224 Many complications associated with obesity are also associated with PsO

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Novo in October 2024 took the extra step of arguing to the FDA that semaglutide is too complex to compound, asking the regulator to include the drug in its Demonstrable Difficulties for Compounding (DDC) listin turn keeping it out of reach for compounders even in times of shortage