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Vitamin B (pyridoxine), when chronically taken in gram quantities, is known to cause a sensory neuropathy, numbness and tingling in the extremities, but the amount of B in this formula (2 mg per mL) is far below such neurotoxic levels

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This makes B12 a promising treatment for diabetic neuropathy

Huemer M, Burer C, Jesina P, Kozich V, Landolt MA, Suormala T, et al