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Some of the so far reported short-term effects are accumulation of toxins on the skin, irritation, (micro) inflammation, oxygen deficiency, clogging of pores, impairment of skin barrier, dryness / lack of moisture, excessive desquamation, pigment spots, altered metabolism as well as protein, lipid, and DNA oxidation

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GIP agonism GIP is secreted by K-cells in jejunum in response to food intake and its physiological role includes stimulation of insulin secretion, increased glucagon secretion, increased lipogenesis and enhancement of lipid buffering capacity (Fig