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Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure

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In vivo, treated mice showed significantly reduced body weights, white adipose masses, and adipocyte sizes findings replicated across multiple independent studies from the same research group

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Some clinical isolates from patients with head and neck cancer exhibit moderate to high fluconazole tolerance, with high-tolerance strains upregulating ERG11 , CDR1 and other genes to maintain biofilm integrity and drug survival under antifungal pressure ( Candida parapsilosis to adapt to caspofungin, replacing rare FKS gene mutations as the primary driver of echinocandin tolerance