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Can you shed some light on this

To the right are widefield images of HeLa cells with lentivirus mediated LUC, Lb NOX, Ec STH, mito Ec STH expression under Dox control transiently expressing SoNar, in basal medium (DMEM without pyruvate, fluorescent vitamins and phenol red with 5 mM glucose, 25 mM HEPES, pH 7.4 and 1% dialyzed FBS), or after addition of 1 M Ant A, or when cells were switched to the basal medium without glucose but with 10 mM pyruvate

This maximizes tolerance but significantly extends time to optimal dosing, potentially losing patients to frustration before benefits fully manifest

The data is sparse and erratic

Presented for research literature review only Kosower EM et al