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They are easy to take, well-studied, and have a solid safety record at doses up to 500 mg per day
As of 2023, most adults earning below 200% of the federal poverty level lacked employer-sponsored insurance, leaving out-of-pocket payment as the only option for accessing the medications unless they were a Medicaid user living in a state where the program covered the drugs
A trial of reperfusion therapy for ischemic stroke indicated that semaglutide, which has a strong GLP-1R-mediated neuroprotective effect, could reduce the infarct size in acute ischemic stroke in non-diabetic rats (89)
Due to the comparative small size of the rats and large size of the defects, these defects would fairly mimic large fistulas in patients that would hardly heal spontaneously
