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Based on clinical trial data, retatrutide produces greater average weight loss (28.7% at 68 weeks with 12mg) compared to tirzepatide (22.5% at 72 weeks with 15mg)
Collins, R
The patient lost 28.7 pounds total but also lost 9.9 pounds of skeletal muscle mass, representing about 35% of total weight lost from lean tissue
However, given their isoform- and context-dependent duality across tumor types, the clinical translation of SIRT modulators requires careful mechanistic stratification and biomarker-guided patient selection
Studies have found it may suppress NF-kB activation, lowering inflammatory cytokine production independently of melanocortin receptors
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