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The most frequent adverse events reported were nausea, constipation, fatigue, decreased appetite, injection site erythema, and injection site reaction, followed by vomiting, headache, diarrhea, dyspepsia, and nasopharyngitis (Table 3)
In the duodenum, pancreatic enzymes break down haptocorrin which allows the pH change to trigger the transfer of B12 to the intrinsic factor (IF) which is a protein made by the stomach
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Avoid hot water and warm environments during an active episode, as heat tends to worsen itching
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