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Full doses of these medications can cause gastrointestinal issues, such as nausea, vomiting, and diarrhea

52 Nevertheless, CD38-deficient old mice preserve the NAD + levels, mitochondrial respiration and metabolic functions

In the absence of gastric acid and not being properly cleaved, vitamin B12 cannot avoid pancreatic digestion leading to lower levels being absorbed (Thongon 2011)