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The role of the ubiquitin proteasome system (UPS) in the heart The UPS as a central and highly selective proteostasis system in cardiomyocytes Alongside autophagy and mitophagy, the ubiquitinproteasome system (UPS) represents a central pillar of cardiac proteostasis, responsible for the highly selective degradation of damaged, misfolded, or regulatory proteins and thereby safeguarding cellular homeostasis and protein turnover (Fig

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Bypasses Regulation: Its design limits its affinity for IGF-binding proteins (IGFBPs), which normally restrict IGF-1's activity

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