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doi: 10.3389/fimmu.2024.1440313 Received 30 May 2024 Accepted 18 November 2024 Published 05 December 2024 Volume 15 - 2024 Edited by Xing Wang, The Affiliated Hospital of Southwest Medical University, China Reviewed by Christoph Hudemann, Philipps-University Marburg, Germany Franziska Roth-Walter, University of Veterinary Medicine Vienna, Austria Updates Copyright 2024 Biedrzycki, Wolszczak-Biedrzycka, Dorf and Maciejczyk
The Biological Explanation The article highlights that GLP-1 therapies work through several biological pathways
Orforglipron, developed by Eli Lilly, is the first non-peptide oral GLP-1 agonist, achieving up to 1.8% HbA1c reduction and 1012% body-weight loss in Phase 3 trials
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